Famclor
F a m c i c l o v i r 250mg
Composition
Each tablet contains
Famciclovir........250mg
Indications and Usage
Treatment of acute herpes zoster (shingles), treatment or suppression of recurrent genital herpes in immunocompetent patients, treatment of recurrent mucocutaneous, herpes simplex infections in HIV-infected patients, treatment of recurrent herpes labialis (cold sores) in immunocompetent patients.
Mode of Action
Famclor is an antiviral. it works by blocking reproduction of the virus.
Pharmcology
Converts to penciclovir, which inhibits viral DNA replication by interfering with viral DNA polymerase.
Pharmacokinetics
Absorption
Bioavailability is about 77%, Tmax is 0.9 h, AUC 0-∞ is 2.24 to 17.9 mcgh/mL depending on dose.Cmax is 0.8 to 6.6 mcg/mL depending on dose.
Distribution
Vd is about 1.08 L/kg;less then 20% bound to plasma proteins.
Metabolism
Route is the liver; deacetylated and oxidized to form inactive penciclovir metabolites.
Elimination
Plasma CI is about 36.6 L/h; about 75% is renally cleared. The t½ is about 2 to 3h.
Storage/Stability
Store Famclor at 25 Degree Centrigarde. breif storage at temprature 15-30 Degree Centrigarade is permitted. Store away from heat, moisture, and light. Keep Famclor out of the reach of Children and away from pets.
Drug Interactions
Digoxin
Famclor may increase digoxin serum concentration.
Probenecid or other drugs significantly eliminated by active renal tubular secretion
May increase famciclovir (penciclovir) serum concentrations.
Laboratory Test interactions
None well documented.
Adverse Reactions
Headache (39%); fatigue (5%); migraine,Paresthesia(3%);confusion, confusional state, delirium, disorientation, hallucinations, somnolence(postmaketing).
Pruritus (4%); rash (3%); serious skin reactions (Including erythema multiforme), urticaria (postmarketing).
Nausea (13%); diarrhea (9%); abdominal pain(8%); flatulence, vomiting(5%), Dysmenorrhea (8%)
Anemia, leukopenia, neutropenia, thrombocytopenia (postmarketing).
jaundice(postmarkeing).
Children
Safety and efficacy not established
Renal Function
Dosage adjustment is recommended when Creatinine Clearance is 60 mL/min or less.
Contraindications.
Famclor is contraindicated in patients with known hypersensitivity to the product, its components.
Presentation
Available in pack of 10 tablets