Composition

Each capsule contains
Acitretin...........25mg
(U.S.P.Specifications)

Indications

Acetin (Acitretin) is a second generation retinoid indicated for the treatment of severe psoriasis in adults i.e., Plaque Psoriasis, Guttate Psoriasis, Inverse Psoriasis, Pustular Psoriasis & Erythrodermic Psoriasis.

Other

Acetin is sometimes also used to treat Darier's disease; palmoplantar pustulosis; lichen sclerosus et atrophicus of the vulva; palmoplantar lichen nitidus; and lichen planus. It is also used to treat lamellar ichthyosis, Sjogren-Larsson syndrome; and bullous and nonbullous ichthyosiform erythroderma.

Dosage

Acetin therapy should be initiated at 25 to 50mg per day, given as a single dose with the main meal Maintenance doses of 25 to 50 mg per day may be given dependent upon an individual patient's response to initial treatment. Relapses may be treated as outlined for initial therapy.

Contraindications And Warnings

For Female Patients

Acetin must not be used by females who are pregnant or who may become pregnant during therapy or at any time for at least 3 years after discontinuation of treatment. Acetin also must not be used by females of reproductive potential who may not use 2 effective forms of contraception (birth control) simultaneously for atleast one month before, during and for atleast three years after treatment. Two effective forms of contraception (birth control) are to be used simultaneously, even when one is a hormonal contraceptive. Patients should not self-medicate with St. John's Wort because of possible interaction with hormonal contraceptives. Prescribers must obtain negative results for 2 pregnancy tests before initiating treatment with Acetin. The first test is a screening test, the second is a confirmation test done during the first 5 days of the menstrual period immediately preceding Acetin therapy. For patients with amenorrhea, the second test should be done at least 11 days after the last act of unprotected sexual intercourse. Timing of pregnancy testing throughout the treatment course should be monthly or individualized based on the the prescriber's clinical judgment. Females must sign a Patient Information/Consent about the risks of birth defects. Acitretin is a metabolite of etretinate and major fetal abnormalities have been repoted with both drugs. Acitretin can interact with ethanol to form etretinate. Therefore, females of reproductive potential must not ingest ethanol during treatment and for 2 months after cessation of treatment. Before prescribing, please see complete pregnancy warning in the accompanying. complete product information. Females who have undergone treatment with etretinate must continue to follow the contraception requirements for etretinate.

For Male Patients

A amall amount of Acetin is present in the semen of male patients who take this medication. It is not known whether this small amount of medication can harm the fetus.

For male and female patients

Do not donate blood while taking Acetin and for 3 year after treatment.
Acetin may cause liver damage. Tell your doctor if you have or ever had liver disease.

Side Effects

Common side effects include; Chelitis, rhinitis, dry mouth, arthralgia, spinal hyperostosis, alopecia, skin peeling, dry skin, nail disorder, pruritus, erythematous rash, hyperesthesia, paresthesia, paronychia, skin atrophy, sticky skin, chapped lips, and alteration in lipids.
Less frequent, but potentially serious, adverse events include; hepatotoxicity, pancreatitis, and pseudotumor cerebri, as well as hyperostosis, bad headaches, nausea, vomiting, blurred vision; decreased vision in the dark, depression, yellowing of your skin, loss of appetite or dark urine, great thirst or hunger, shortness of breath, alteration in lipids with possible cardiovascular effects, and ophthalmologic effects.

Presentation

Acetin Capsules are available in Alu-Alu blister pack of 30's.

FURTHER INFORMATION

For further Details info@inceptapharmapk.com